ANDERSON,James Morley 教授
Professor of Pathology, Macromolecular Science and Biomedical Engineering
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Wisconsin State University at Eau Claire    B.S.     1963     Chemistry

Oregon State University                  Ph.D.    1967     Organic Chemistry

Case Western Reserve University         M.D.    1976      Medicine
Positions and Honors.

   Positions and Employment

1970-1976  Senior Research Associate, Department of Macromolecular Science, Case Western Reserve University (CWRU), Cleveland, OH

1976-1981   Assistant Professor of Macromolecular Science, CWRU

1976-1979   Assistant Professor of Pathology, CWRU

1979-      Pathologist, Department of Pathology, University Hospitals of Cleveland, OH

1980-1984  Associate Professor of Pathology, CWRU

1982-1984  Associate Professor of Biomedical Engineering, CWRU

1981-1984  Associate Professor of Macromolecular Science, CWRU

1984-      Professor of Pathology, Macromolecular Science and Biomedical Engineering, CWRU

Other Experience and Professional Memberships

1988-      Editor-in-Chief, Journal of Biomedical Materials Research

1990-      Chairman, ISO 10993-1 Committee, Biological Response Evaluation of Medical Devices

under a Risk Management Program

1993-      Consultant NHLBI Total Artificial Heart (TAH) Program

2003-2004  President, Controlled Release Society


2006      Honoris Causa (Honorary Doctorate of Philosophy Degree), University of Geneva

2006      Chugai Mentoring Award, American Society for Investigative Pathology (ASIP)

2005      Elsevier Gold Medal – For the most significant overall contribution to biomaterials

          science by an individual from 1980 to 2005

2003-     Member, Institute of Medicine of the National Academies

2003      John R. Carter Award for Excellence in Medical Student Teaching, Institute of Pathology,


1993-2003 Method to Extend Research in Time (MERIT) Award, National Institutes of Health,

         Heart, Lung, and Blood Institute

2000      Excellence in Surface Science Award, Surfaces in Biomaterials Foundation

1997      Founders Award, Society for Biomaterials (USA)

1997      Founders Award, Controlled Release Society

1994      Fellow, FBSE, Biomaterials Science and Engineering

1993      Fellow, American Institute of Medical Biological Engineering, AIMBE

Selected peer-reviewed publications (in chronological order). 

     (Publications selected from 280 peer-reviewed publications)

1.   Shive, M.S., M.L. Salloum, and J.M. Anderson, Shear stress-induced apoptosis of adherent neutrophils: A mechanism for persistence of cardiovascular device infections. PNAS 2000;97:6710-6715.

2.   Anderson, J.M., Multinucleated giant cells. Curr. Opin. Hematol. 2000;7:40-47.

3.   Wood, E.M., E. Colton, R.A. Yomtovian, L.M. Currie, J. Connor, and J.M. Anderson, Prevention of monocyte adhesion and inflammatory cytokine production during blood platelet storage: An in vitro model with implications for transfusion practice. J. Biomed. Mater. Res. 2000;51:147-154.

4.   Shive, M.S., W.G. Brodbeck, E. Colton, and J.M. Anderson, Shear stress and material surface effects on adherent human monocyte apoptosis. J. Biomed. Mater. Res. 2002;60:148-158.

5.   McNally, A.K. and J.M. Anderson, Beta1 and Beta2 integrins mediate adhesion during macrophage fusion and multinucleated foreign body giant cell formation. Amer. J. Pathol. 2002;160:621-630.

6.   Brodbeck, W.G., M.S. Shive, E. Colton, N.P. Ziats, and J.M. Anderson, Interleukin-4 inhibits tumor necrosis factor-α-induced and spontaneous apoptosis of biomaterial-adherent macrophages. J. Lab. Clin. Med. 2002;139:90-100.

7.   Brodbeck, W.G., J. Patel, G. Voskerician, E. Christenson, M.S. Shive, Y. Nakayama, T. Matsuda, N.P. Ziats, and J.M. Anderson, Biomaterial adherent macrophage apoptosis is increased by hydrophilic and anionic substrates in vivo. PNAS 2002;99(16):10287-10292.

8.   Shive, M.S., W.G. Brodbeck, and J.M. Anderson, Activation of Caspase 3 during shear stress-induced neutrophil apoptosis on biomaterials. J. Biomed. Mater. Res. 2002;62(2):163-168.

9.   Brodbeck, W.G., Y. Nakayama, T. Matsuda, E. Colton, N.P. Ziats, and J.M. Anderson, Biomaterial surface chemistry dictates adherent monocyte/macrophage cytokine expression in vitro. Cytokine 2002;18(6):311-319.

10. Brodbeck, W.G., G. Voskerician, N.P. Ziats, Y. Nakayama, T. Matsuda, and J.M. Anderson, In vivo leukocyte cytokine mRNA response to biomaterials is dependent on surface chemistry. J. Biomed. Mater. Res. 2003;64A(2):320-329.

11. Patel, J.D., M. Ebert, K. Stokes, R. Ward, and J.M. Anderson, Inhibition of bacterial and leukocyte adhesion under shear stress conditions by material surface chemistry. J. Biomater. Sci. Polymer Edn. 2003;14(3):279-295.

12. Voskerician, G., M.S. Shive, R.S. Shawgo, H. von Recum, J.M. Anderson, M.J. Cima, and R. Langer, Biocompatibility and biofouling of MEMS drug delivery devices. Biomaterials 2003;24:1959-1967.

13. Brodbeck, W.G., E. Colton, and J.M. Anderson, Effects of adsorbed heat labile serum proteins and fibrinogen on adhesion and apoptosis of monocytes/macrophages on biomaterials. J. Mater. Sci., Mater. In Medicine 2003;14:671-675.

14. Dadsetan, M., E.M. Christenson, F. Unger, M. Ausborn, T. Kissel, A. Hiltner, and J.M. Anderson, In vivo biocompatibility and biodegradation of poly(ethylene carbonate). J. Contr. Rel. 2003;93(3):259-270.

15. McNally, A.K. and J.M. Anderson, Foreign body-type multinucleated giant cell formation is potently induced by α-Tocopherol and prevented by the diacylglycerol kinase inhibitor R59022. Amer. J. Pathol. 2003;163(3):1147-1156.

16. Christenson, E., J.M. Anderson, and A. Hiltner, Oxidative mechanisms of poly(carbonate urethane) and poly(ether urethane) biodegradation: in vivo and in vitro correlations. J. Biomed. Mater. Res. 2004;70A:245-255.

17. Maeyama, R., Y. Mizunoe, J.M. Anderson, M. Tanaka, and T. Matsuda, Confocal imaging of biofilm formation process using fluoroprobed Escherichia coli and fluorostained exopolysaccharide. J. Biomed. Mater. Res. 2004;70A:274-282.

18. Dadsetan, M., J.A. Jones, A. Hiltner, and J.M. Anderson, Surface chemistry mediates adhesive structure, cytoskeletal organization, and fusion of macrophages. J. Biomed. Mater. Res. 2004;71A:439-448.

19. Voskerician, G., R.S. Shawgo, A.P. Hiltner, J.M. Anderson, M.J. Cima, and R. Langer, in vivo inflammatory and wound healing effects of gold electrode voltammetry for MEMS micro-reservoir drug delivery device. IEEE Transactions on Biomedical Engineering 2004;51(4):627-635.

20. Christenson, E.M., M.J. Wiggins, J.M. Anderson, and A. Hiltner, Surface modification of poly(ether urethane urea) with modified dehydroepiandrosterone for improved in vivo biostability. J. Biomed. Mater. Res. 2005;73A:108-115.

21. Patel, J.D., Y. Iwasaki, K. Ishihara, and J.M. Anderson, Phospholipid polymer surfaces reduce bacteria and leukocyte adhesion under dynamic flow conditions. J. Biomed. Mater. Res. 2005;73A:359-366.

22. Christenson, E.M., M. Dadsetan, J.M. Anderson, and A. Hiltner, Biostability and macrophage-mediated foreign body reaction of silicone-modified polyurethanes. J. Biomed. Mater. Res. 2005;74A(2):141-155.

23. Brodbeck, W.G., M. MacEwan, E. Colton, H. Meyerson, and J.M. Anderson, Lymphocytes and the foreign body response: Lymphocyte enhancement of macrophage adhesion and fusion. J. Biomed. Mater. Res. 2005;74A(2):222-229.

24. MacEwan, M.R., W.G. Brodbeck, and J.M. Anderson, Monocyte/lymphocyte interactions and the foreign body response: In vitro effects of biomaterial surface chemistry. J. Biomed. Mater. Res., 2005;74A(3):285-293.

25. Ebert, M., B. Ward, J. Anderson, R. McVenes, and K. Stokes, In vivo biostability of polyether polyurethanes with polyethylene oxide surface-modifying end groups; Resistance to biologic oxidation and stress cracking. J. Biomed. Mater. Res. 2005;75A(1):175-184.

26. Chandra, J., J.D. Patel, J. Li, P.K. Mukherjee, T.S. McCormick, J.M. Anderson, and M.A. Ghannoum, Modification of surface properties of biomaterials influences the ability of C. albicans to form biofilms. Applied and Environmental Microbiology 2005;71(12):1-7.

27. Voskerician, G., C.-C. Liu, and J.M. Anderson, Electrochemical characterization and in vivo biocompatibility of a thick-film printed sensor for continuous in vivo monitoring. IEEE Sensors Journal 2005;5(6):1147-1158.

28. McNally, A.K. and J.M. Anderson, Multinucleated giant cells formation exhibits features of phagocytosis with participation of the endoplasmic reticulum. Exper. and Molec. Pathol. 2005;79:126-135.

29. Christenson, E.M., J.M. Anderson, and A. Hiltner, Antioxidant inhibition of poly(carbonate urethane) in vivo biodegradation. J. Biomed. Mater. Res. 2006;76A:480-490.

30. Ward, R., J. Anderson, M. Ebert, R. McVenes, and K. Stokes, In vivo biostability of polysiloxane polyether polyurethanes; resistance to metal ion oxidation. J. Biomed. Mater. Res. 2006;77A(2):380-389.

31. Ward, R., J. Anderson, R. McVenes, and K. Stokes, In vivo biostability of polyether polyurethanes with fluoropolymer and polyethylene oxide surface modifying endgroups; resistance to biologic oxidation and stress cracking. J. Biomed. Mater. Res. 2006;77A(3):580-589.

32. Christenson, E.M., J.M. Anderson, and Hiltner, Relationship between nanoscale deformation process and elastic behavior of polyurethane elastomers. Polymers 2006; in press.

33. Patel, J.D., T. Krupka, and J.M. Anderson, iNOS mediated generation of nitric oxide and superoxide anion by biomaterial adherent neutrophils. J. Biomed. Mater. Res. 2006; in press.

34. Weinberg, B.D., E. Blanco, S.F. Lempka, J.M. Anderson, A. Exner, and J. Gao, Combined radiofrequency ablation and doxorubicin-eluting polymer implants for liver cancer treatment. J. Biomed. Mater. Res. 2006; in press.

35. MacKintosh, E.E., J.D. Patel, R.E. Marchant, and J.M. Anderson, Effects of biomaterial surface    chemistry on the adhesion and biofilm formation of S. epidermidis in vitro. J. Biomed. Mater. Res. 2006; in press.

Further information is available from Secretariat, Donghua University

Shanghai, 201620, P.R.China




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